FNDC5 is produced in the stomach and associated to body composition
نویسندگان
چکیده
The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present data shows FNDC5 gene expression in the gastric mucosa. Immunohistochemical studies found FNDC5 immunopositivity in chief cells of gastric tissue. By the use of three different antibodies FNDC5 was found expressed in gastric mucosa and secreted by the stomach. The rate of gastric FNDC5 secretion parallels the circulating levels of FNDC5. The body fat mass increase after intervention with high fat diet coincided with a decrease in the secretion of FNDC5 from the stomach and a diminution in the FNDC5 circulating levels. In summary, the present data shows, for the first time, the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis.
منابع مشابه
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
متن کاملبررسی ترکیب بدن سالمندان شهر تهران و ارتباط آن با الگوی فعالیت فیزیکی سال 1393
Background and purpose: Aging is associated with changes in body composition which could lead to malnutrition and disability in elderly people. Physical activity is one of the most important factors that can affect changes in body composition in this population. The purpose of this study was to investigate body composition in elderly and its relationship with pattern of objectively measured phy...
متن کاملLocus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?
The transmembrane protein FNDC5 was recently characterized as precursor of an exercise induced myokine named irisin. Previous studies found a relationship between circulating irisin levels and muscle mass in humans. Consequently, we tested the hypothesis whether FNDC5/irisin is involved in the modulation of body composition in cattle. Since information on the bovine FNDC5 locus was scarce, we c...
متن کاملRole of Probiotics in the Management of Helicobacter Pylori Infection
Helicobacter pylori is a gram-negative, spiral-shaped, microaerophilic organism that colonizes the stomach of humans and causes chronic-active gastritis, peptic ulcer disease, and gastric cancers, including adenocarcinoma of the stomach and MALT (mucosal-associated lymphoid tumor) lymphomas. H. pylori colonizes the stomach of over 50 % the world’s human population, primarily those who reside in...
متن کاملCorrelation of dietary protein intake with body composition and physical status in patients with knee osteoarthritis
Background and Objectives: Little is known about the association between dietary protein intake and clinical manifestations in osteoarthritis (OA) patients. We aimed to determine the correlation between dietary protein intake and pain severity, functional status, and body composition indices in patients with knee OA. Materials and Methods: This cross-sectional study was performed on 220 OA pat...
متن کامل